STUDIES ON FORMULATION AND EVALUATION OF ORALLY DISINTEGRATING TABLETS USING MUSA ACUMINATA AS A NATURAL DISINTEGRANT FOR PAEDIATRIC USE

The aim of the present study was to optimize an orally disintegrating tablet of ibuprofen (~100mg) using Musa acuminata (dehydrated banana powder) as a natural super disintegrant. In this work, dehydrated banana powder was used as pharmaceutical excipient because of natural origin and high nutrition properties for paediatric formulation. These tablets were prepared by direct compression technique and compared with formulations made by using synthetic super disintegrants Croscarmellose sodium, micro crystalline cellulose and Cross povidone. FTIR studies of formulations have shown no interactions between drug and excipients. In vitro disintegration and in vitro dissolution profiles were shown that comparative disintegration properties of dehydrated banana powder to that of commonly used synthetic super disintegrants. Short term stability study indicated that formulations were stable for three months. It can be concluded that dehydrated banana powder can be used as natural super disintegrant effectively in paediatric dosage forms and also shows promise as a nutritional pharmaceutical excipient.