IN VITRO ANTIMALARIAL ACTIVITY OF THAI PICRASMA JAVANICA Bl STEM EXTRACT

The in vitro antimalarial activity against Plasmodium falciparum K1 of the four extracts from the stem of Picrasma javanica Bl, that is, water, methanol, chloroform and hexane were studied using a modification of the [3H]hypoxanthine incorporation method. It was found the chloroform and hexane extracts showed in vitro antimalarial activity with IC50 of 21.6 g/ml and 33.2 21.6 g/ml, respectively. While, the methanol and water extracts were inactive against parasite. In addition, the methanol extract of leave showed the activity against P. falciparum K1 with IC50 of 21.7 g/mL. Chemical constituent investigations of stem and leave of this medicinal plant may bring to the new lead structures for developing new antimalarial drugs.