APLASTIC ANEMIA WITH SUB CONJUNCTIVAL HAEMORRHAGE AND PAROXYSMAL NOCTURNAL HAEMOGLOBINURIA: A RARE CASE REPORT

This Case report describes a case of idiopathic acquired aplastic anemia in an 18-year-old male patient with petechial rash, sub conjunctival haemorrhage and paroxysmal nocturnal haemoglobinuria. Patient was treated with elthrombopag olamine- 50mg and cyclosporine- 200mg these two drugs are showing good response in most of the patients with Aplastic anemia in the absence of human leucocytes antigen (HLA) matched sibling donor. In some studies good response was shown for elthrombopag olamine 150mg/day. In this patient only 50mg of elthrombopag olamine is given, patient was died because of the febrile neutropenia. The dose adjustment of drugs in this patient was necessary; this is the responsibility of clinical pharmacist by giving suggestions to physician to adjust the doses as per the patient response towards the therapy. Keywords: Aplastic anaemia, proximal nocturnal hemoglobinuria, Elthrombopag olamine, subconjuctival haemorrhage