A study on association of Helicobacter pylori in gastric disorders

Introduction: Helicobacter pylori are a ubiquitous organism that can be seen in 50% of general population. Its association with various gastric disorders are well established in numerous studies after its discovery in 1983. Peptic ulcer disease is the most studied disease related to H Pylori infection. H. pylori are seen in 90% of duodenal ulcer and 75% of gastric ulcer Patients. This bacterium is also involved in the pathogenesis of several extra gastric diseases, such as mucosa-associated lymphoid tissue lymphomas (Maltomas) gastroesophageal reflux disease (GERD) and gastric carcinomas. In some population Pylori can be seen associated in 80% of gastric cancers. Aim of the study: To study the association of H pylori in benign and malignant disorders of stomach and to study presence of H pylori in association with different histological types of carcinoma stomach and benign gastric diseases (such as gastritis, gastric ulcers, erosions and polyps). Materials and methods: A detailed clinical history was elucidated, followed by careful clinical examination, which were recorded as per the proforma. All the patients included in the study underwent upper gastrointestinal endoscopy and the findings were noted Results: In the study males have a preponderance to have both benign and malignant disorders. In benign group 66% were males and 34% were females. In the malignancy group 78% were males and 22% were females. Of the benign group gastritis is most common. In malignant group poorly differentiated carcinomas are more common. Conclusion: The incidence and mortality from gastric cancer and the morbidity from benign gastric disease are progressively decreasing worldwide, but gastric cancer remains a major public health problem in several developed and developing countries, especially in Asia. Gastric cancer has an extremely poor prognosis since a 5-year survival rate using currently available treatments, surgery and radio-chemotherapy, is less than 20%.