RESTRAIN OF FEAR: PARTICIPATION OF GABA NEUROTRANSMITTER SYSTEM
Journal: Problems of Psychology in the 21st Century (Vol.6, No. 1)Publication Date: 2013-07-22
Authors : Galina I. Shulgina; Darya A. Berezhnaya; Nikolai A. Parfentyev;
Page : 71-85
Keywords : training; freezing; fear; inhibition; disinhibition; GABA; Phenibut;
Abstract
In experiences on rats in the conditions of free behavior at development of a conditioned of passive avoidanсe reflex (the first series) and a defensive reflex and a conditional inhibition (the second series) it is revealed, and elaboration of internal inhibition and Phenibut – a nonspecific agonist of GAMKA and GAMKB receptors cause in experimental animals weakening of freezing arising in a dangerous situation, and a disinhibition of research behavior. Results of experiences in the accounting of data of the literature allow to assume that both factors, and elaboration of internal inhibition, and Phenibut weaken freezing – the phenomenon used in experiments as a biological analog of fear, owing to increase of level of activity of the GABA neurotransmitter system of a brain.
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