DIFFERENTIAL PULSE VOLTAMMETRIC DETERMINATION OF CINITAPRIDE USING CARBON PASTE ELECTRODE

The voltammetric performance of cinitapride (CNTP) was investigated at carbon paste electrode using differential pulse voltammetry and cyclic voltammetry. The drug under study exhibited a single, well-defined reduction peak owing to the reduction of NO2. The electrode and reaction conditions which yielded maximum peak current were established using differential pulse voltammetry. A linear relationship was observed between the peak current and the concentration of CNTP over the range 2.35x10-6 M to 4.25x10-4M. The limits of detection and limits of quantitation were found to be 6.55x10-9 M to 7.42x10-8M respectively. The proposed method was successfully applied for the determination of CNTP in pharmaceutical formulations without interference from excipients