DEVELOPMENT OF A COMPOSITE OF POLY-Ɛ-CAPROLACTONECERIUM OXIDE

Nanotechnology is used in a variety of sectors for the manufacture of materials. However, there is a risk from exposure to nanomaterials due to their chemical composition and processing form, giving rise to health risks. CeO2 particles present antioxidant properties that accelerate the wound poly-Ɛ-caprolactone (PCL) provides the property of biocompatibility and biodegradability of the material. For the regulation of the transport and release of cerium oxide particles was incorporated into a polymeric matrix composed of PCL. Therefore, in this study we propose the elaboration of a composite material of poly-Ɛ-caprolactone-cerium by the electrospinning technique. Electrospinning for example has been widely used to fabricate scaffolds imitating the structure of natural extracellular matrix. The fibers obtained with an average diameter of 600 nm was characterized by confocal microscopy, scanning electron microscopy, infrared spectroscopy, Differential thermal analysis, Thermogravimetric Analysis and Differential Scanning Calorimetry. Additionally, genotoxic effect was evaluated by comet assay in Vicia faba cell nuclei, results show that the material made has no genotoxic effects in Vicia faba cells.