DIAGNOSTICS AND PROGNOSIS OF DESTRUCTIVE ULCERATIVE MUCOSAL LESIONS OF THE STOMACH AND DUODENUM ON THE BASIS OF ASSESSMENT OF ELASTASE INHIBITOR SYSTEM IN CHILDREN WITH CONNECTIVE TISSUE DYSPLASIA

Purpose of research. Concern about proteases development is defined by their key role in many processes of vital functions of an organism. The aim of this study was to estimate the activity of elastase inhibitor system in children with chronic gastroduodenitis and chronic gastroduodenitis associated with connective tissue dysplasia. Material and methods. Proteolytic-antiproteolytic system activity has been assessed in 140 children with chronic gastroduodenitis. The level of elastase and its main inhibitors was estimated by L. Vesser method, α1-AT and α2–М - V. F. Nartikova method. Results. The results of the study indicate, that children with chronic gastroduodenitis associated with connective tissue dysplasia have a high activity of proteolytic and low activity of antiproteolytic system, which requires correction of the treatment. In patients with the concentration of elastase 0,41 Int.Units/ml and higher and the total inhibitory capacity of blood less than 37,4 Inhib.Units/ml with the high positive predictive value erosions and gastric ulcer can be suspected. Conclusion. The level of elastase and its inhibitors can serve as a marker of progressing destructive and ulcerative lesions of the mucous membrane of the stomach and duodenum in children.