COMPARISON OF DRUG RELEASE PROFILE OF DIFFERENT BRANDS OF DICLOFENAC POTASSIUM

Diclofenac Potassium is most commonly used analgesic. To analyze the quality of seven market brands of diclofenac potassium the present study was designed. These seven brands of Diclofenac potassium tablet formulation was manufactured by various pharmaceutical companies. To evaluate their quality these different brands of tablet were checked for varies parameter like disintegration time, weight variation, friability, hardness and dissolution profile by using standard techniques. The results obtained were compared with the standards and all the market brands of diclofenac gave excellent disintegration, hardness, weight variation and friability result. Among all the brands the multinational companies' products showed comparatively better results. The release pattern of diclofenac potassium different brands was within 45 minutes and purity range was 80% to 101%. All the results were within limit and were found satisfactory. Therefore it can be concluded that all the diclofenac potassium different brands that are available in Pakistan fulfill the USP specification for quality control analysis. Key words: Quality control, weight variation, Disintegration, Hardness, Release profile.