STUDIES ON THE SYNTHESIS OF SOME NEW 1,2,4- TRIAZOLES DERIVATIVES AND EVALUATION FOR THEIR ANTI-FUNGAL ACTIVITY PROFILES

Abstract: The synthesis of new heterocyclic compounds has always drawn the attention of medicinal chemist over the years mainly because they possess diverse biological properties. The literature survey on 1,2,4-triazoles revealed that they are endowed with wide variety of biological activities .During the present investigation a series of new 1,2,4-triazole derivatives N-(3-(2-(3- hydrazinyl-3-oxoalkanoyl)hydrazinyl)-5-(phenoxymethyl)-4H-1,2,4-triazol-4-yl)isonicotinamide(6a- 6e)were synthesized by reacting withN-(5-mercapto-3-(phenoxymethyl)-4H-1,2,4-triazol-4- yl)isonicotinamide (5) and aliphatic dicarboxylic acid hydrazides (a-e). The structures of the newly All the compounds synthesised 6a to 6e were evaluated for antifungal activity against Candida albicans and Aspergillus Niger was carried out and MIC values were determined synthesized compounds were estblished by FT-IR, 1H-NMR and MASS spectral analysis. The compound 6a (n=0) was found to be the most potent antifungal agent. Keywords: 1,2,4-triazole derivatives, antifungal, Candida albicans, Aspergillus Niger