PHASE SOLUBILITY STUDIES OF IBUPROFEN WITH β-CYCLODEXTRIN AND HYDROXY PROPYL- β CYCLODEXTRIN IN DIFFERENT BUFFER MEDIA

An oral route of drug administration is the most common and preferred method of delivery due to its convenience and ease of ingestion, but for many of drugs it can be hard way due to poor solubility. As the therapeutic activity of drugs is related to their solubility in water, in case of poorly water-soluble drugs, dissolution is the rate-limiting step in the process of drug absorption hence will lead to low bioavailability. To overcome the problems related with oral absorption and bioavailability issue, several strategies have been utilized including hydrotrpes, complexation, microcapsulation, use of surfactants, permeation enhancers, micronization, salt formation, Cyclodextrins, nanoparticles, solid dispersions, self emulsifying drug delivery system. By the early 1950s the basic physicochemical characteristics of cyclodextrins had been discovered and are widely used for the solubilization of poorly soluble drugs in the formulations. The versatile pharmaceutical material cyclodextrins (CDs) are classified into hydrophilic, hydrophobic, and ionic derivatives. Ibuprofen is a non steroidal anti-inflammatory drug and it is used as an analgesic, antipyretic and anti-inflammatory in the treatment of pain. It is very slightly soluble in water (<1 mg/ml, BCS class II) and its absorption could be a prerequisite for the quick onset of its action. In the present study solubility of ibuprofen was studied in presence of β- cyclodextrin and Hydroxypropyl- β- cyclodextrin at different pH . The stability constant (Kc) for ibuprofen in presence of β- cyclodextrin at 7.4, 7.2 and 6.8 were 1368.03, 56.7525 and 74.2418 respectively. Similarly, stability constant (Kc) in presence of hydroxy propyl-β-cyclodextrin at 7.4, 7.2 and 6.8 were 790.095, 143.684 and 372.055 respectively. The solubility of ibuprofen in presence of Hydroxypropyl- β-cyclodextrin was found more than and β- cyclodextrin at pH 7.2. Keywords: Ibuprofen, Inclusion Complex, Phase Solubility, β- Cyclodextrin, Hdroxyl Propyl β- Cyclodextrin.