BIOLOGICAL EVALUATION OF NOVEL A-HETEROARYL/ARYLAZO 2-NAPHTHOL ANALOGS AND THE TRANSITIONAL METAL COMPLEXES DERIVED FROM 4-((2-HYDROXYNAPHTHALEN-1-YL) DIAZENYL)-1, 5-DIMETHYL-2-PHENYL-1H-PYRAZOL-3(2H)-ONE

Eight different aryl / heteroarylazo substituted 2-naphthol congeners and complexes of the composition [M (L) 2 (H2 O) 2 ]. x H2 O where L is deprotonated ligands such as 4g (ligH): 4-((2-hydroxynaphthalen-1- yl) diazenyl)-1, 5-dimethyl-2-phenyl-1H-pyrazol-3(2H)-one and M= Cu(II), Ni(II) and Co(II) have been synthesized. The structures of the synthesized compounds have been confirmed by different modern analytical techniques. The results of antimicrobial activities of the novel synthesized 2-naphthol congeners reveled that the 4-carboxyphenylazo substituted 2-naphthol analog 4h showed significant antibacterial activity against Escherichia coli, Salmonella enterica ser.typhi, Salmonella enterica typhimurium, Shigella flexneri, Pseudomonas aeruginosa, Vibrio cholera, Micrococcus luteus, Pectobacterium carotovorum, Bacillus subtilis and Staphylococcus aureus in comparison to standard. However the nickel complex of 4g showed significant antifungal activity against T. rubrum and C. glabrata. The novel synthesized azo molecules may be suggested for the establishment of new search for antimicrobial agents and to create an opportunity in new drug discovery and medicinal research.