SYNTHESIS, CHARACTERIZATION AND PHARMACOLOGICAL EVALUATION OF SUBSTITUTED 1, 2, 4-TRIAZOLE DERIVATIVES

A series of 2-(4-substituted)-5-mercapto-4H-1,2,4-triazol-3-yl)phenols (3a-3f) and 3-(3-(2-hydroxyphenyl)5-mercapto-4H-1,2,4-triazol-4-yl)-2-substituted thiazolidin-4-ones (4a-4f) were designed and synthesized. The synthesized compounds were characterized by IR, 1h-NmR and elemental analysis. The synthesized compounds were evaluated for analgesic and anti-inflammatory activity. Among the tested compounds, compounds 3b and 4e showed potent analgesic activity and compounds 3b and 3e have shown promising anti-inflammatory activity.