PREPARATION AND EVALUATION OF SUSTAINED RELEASE MICRO EMULSION OF CEFPODOXIME PROXETIL

Now a day oral route is the easiest and most prominent route for drug delivery. More than 40% of new chemical entities exhibit poor aqueous solubility result in unsatisfactory oral drug delivery. Cefpodoxime Proxetil is a Class IV drug, possess lower solubility and lower bioavailability. The aim of this study was to formulate and evaluate a Micro emulsion to overcome these issues. Capmul MCM was selected as an oily phase, tween 80 as a surfactant and PEG 400 as a co-surfactant. The batches of emulsion were formulated by spontaneous emulsification method. Different concentrations of Surfactant and Co. Surfactant were used to formulate micro emulsion. Evaluation parameters such as Globule size, pH, Viscosity, Clarity, Dilution test, Centrifugation and Freeze Thaw method were tested. %CDR, Drug content and Anti-microbial assay were also calculated. Keywords: Micro Emulsion, Cefpodoxime Proxetil, Globule size, Freeze Thaw, Anti-microbial