INSILICO DOCKING BASE ANALYSIS OF DRUG CANDIDATES AGAINST MYCOBACTERIUM TUBERCULOSIS

Mycobacterium tuberculosis is an obligate pathogenic bacterial species in the family Mycobacteriaceae and the causative agent of tuberculosis. Mycobacterium tuberculosis has an unusual, waxy coating on its cell surface. Tuberculosis is caused by bacteria that spread from person to person through microscopic droplets released into the air. This can happen when someone with the untreated, active form of tuberculosis coughs, speaks, sneezes, spits, laughs or sings. Isoniazid ,Rifampicin,Pyrazinamide,Ethambutol,Streptomycin are the drugs of mycobacterium tuberculosis.The tools used for retrieve the structure and sequence of ESAT-6 associated with M.Tuberculosis,are Protein Data Bank,PUBCHEM, CHEMSKETCH, OPEN BABEL, UCSF CHIMERA,CYGWIN.