The Effect of Erythropoietin on Ovarian Epithelium Karyorrhexis during Ischemia Reperfusion Injury in Rats

The aim of this experimental study was to examine the effect of erythropoietin on rat model and particularly in an ovarian ischemia reperfusion (IR) protocol. The effect of that molecule was studied pathologically using the mean ovarian epithelium karyorrhexis (OK) lesions. Materials and methods: 40 rats of mean weight 247.7 g were used in the study. OK lesions were evaluated at 60 min (groups A and C) and at 120 min (groups B and D) of reperfusion. Erythropoietin was administered only in groups C and D. Results were that Epo administration non-significantly decreased the OK scores by 0.15 without lesions [-0.371518 - 0.071518] (p= 0.1679). Reperfusion time non-significantly increased the OK scores by 0.1 without lesions [-0.27768095 – 0.14211844] (p=0.4073). However, Epo administration and reperfusion time together non-significantly decreased the OK scores by 0.0818182 without lesions [-0.2159977 - 0.0523614] (p=0.2246). Conclusions: Results of this study indicate that Epo administration interacted or not with reperfusion time non-significantly short-term decreased the OK scores. Perhaps, a longer study time than 2 hours may provide more significant effects.