SYNTHESIS, SPECTRAL STUDIES AND ANTIANXIETY ACTIVITY OF SOME SCHIFF BASES OF 4-(AMINO)-5-PHENYL-4H-1,2,4-TRIAZOLE-3-THIOLS

A series of 4-(4-substituted benzylideneamino)-5-phenyl-4H-1,2,4-triazole-3-thiols (IVa-e) was obtained by reaction of 4-(amino)-5-phenyl-4H-1,2,4-triazole-3-thiol with aromatic aldehyde in presence of concentrated sulphuric acid. The synthesised compounds were characterized by FT-IR, 1H-NMR and mass spectra data. The compounds (IVa-e) were screened for their antianxiety activity. Among the compounds, IVa and IVe were found to be the most acitive antianxiety compounds.