ANTIVIRAL ACTIVITY OF HERBAL IMMUNOMODULATORY PREPARATIONS NCV I AND AC II – AND THEIR USEFULNESS IN HIV INFECTION
Journal: Indian Drugs (Vol.52, No. 11)Publication Date: 2015-11-28
Authors : Tharakan S. T.; Binitha P. P.; Kuttan R.; Kuttan G.;
Page : 50-55
Keywords : ;
Abstract
NCV I and AC II are the two herbal immunomodulatory preparations being used in our centre for the treatment of acquired immunodeficiency syndrome (AIDS) for the past 20 years. The objective of this study is to check whether these drugs possess any antiviral activity in vitro and in vivo. In vitro antiviral activity was determined using Vero cells against Poliovirus. In vivo antiviral activity was determined in chick and duck embryonated eggs using New Castle Disease Virus (NDV), Egg Drop Syndrome (EDS) virus and also in NDV vaccinated chicks. NCV I and AC II decreased growth of poliovirus in culture. When the virus-inoculated Vero cells were treated with NCV I, the viral growth was inhibited by 59.87% and with AC II it was inhibited by 70.06%. When the chick embryos were treated with these viruses, there was no immediate lethality for 5 days but the haemagglutination titre (HA) was found to be significantly increased indicating an increase in viral load. The haemagglutination titre for NDV alone was found to be 1024 against normal untreated value of 128. In EDS treated duck eggs HA titre was found to be 4096. These titres were reduced to 4 in NCV I and 8 in AC II treated duck embryos. NCV I and AC II were also found to decrease the HA titre in chicks treated with NDV. These studies indicated the effectiveness of NCV I and AC II in HIV could be partially due to its antiviral activity against human immunodeficiency virus.
Other Latest Articles
- OPTIMIZATION OF RP-HPLC METHOD BY 32 – CENTRAL COMPOSITE DESIGN FOR THE VALIDATION AND ESTIMATION OF DOXYCYCLINE HYCLATE IN BULK DRUG AND FORMULATIONS
- Removable Watermarking Sebagai Pengendalian Terhadap Cyber Crime Pada Audio Digital
- Classification of Radar Environment Using Ensemble Neural Network with Variation of Hidden Neuron Number
- Fabrication of Hybrid Polymer Solar Cells By Inverted Structure Based on P3HT:PCBM Active Layer
- Analisa Kinerja Teknik Modulasi Digital pada Kanal Optik Nirkabel
Last modified: 2017-09-07 14:21:20