FORMULATION AND OPTIMIZATION OF CEFIXIME TRIHYDRATE DISPERSIBLE TABLETS BY DIRECT COMPRESSION TECHNIQUE

The optimized formulation of cefixime dispersible tablets were developed using super disintegrants sodium starch glycolate and crospovidone. D-optimal design is used to optimize the formulation of cefixime dispersible tablet to study the effective concentration of independent variables SSG, crospovidone and MCC on responses (dependent variables) i.e. dispersion time, % drug release and % friability. Twelve formulations were prepared and evaluation of pre-compression and post compression parameters of tablets was perfomed. Analysis of variance (ANOVA) probability (p)