EFFECT OF DAUCUS CAROTA AND FUMARIA INDICA ON GASTRIC TISSUE GLUTATHIONE LEVEL IN INDOMETHACIN INDUCED ULCERS

The present study was undertaken to evaluate the effects of roots of Daucus carota and aerial parts of Fumaria indica on gastric tissue glutathione level in experimental rats with indomethacin-induced gastric ulceration. Ethanol extract from roots of D. carota and aerial parts of F. indica was administered at the doses 100 and 200 mg/kg/day, p.o. Ulcer index, gastric GSH level and gastric wall mucus level were estimated. The functioning of liver was also assayed. The effects of roots of D. carota and aerial parts of F. indica were significant and comparable to reference treated group of rats. The gastric GSH levels were replenished by both D. carota and F. indica in 200 mg/kg each. From this study, it was concluded that ethanol extracts each from roots of D. carota and aerial parts of F. indica posses significant ulcer protection by replenishing Gastric GSH and increasing gastric mucus level.