THE CONTENT OF MCP-1 AND MMP-9 IN BLOOD SERUM OF PATIENTS WITH CHRONIC POLYPOID RHINOSINUSITIS

The content of MCP-1 and MMP-9 inblood serum of patients with chronic polypoid rhinosinusitis was studied. It was found that this pathology led to a significant increase in MCP-1, which is a marker of fibrosis, in blood serum. The compensatory increase in MMP-9, serving as an antifibrotic factor, is much weaker. Such imbalance between profibrotic MCP-1 and antifibrotic MMP-9 indicates a lack of compensatory adaptation mechanisms of fibrolysis activation and contributes to the development of fibrosis in chronic polypoid rhinosinusitis.