FORMULATION OF CONTROLLED RELEASE DRUG DELIVERY OF LORNOXICAM

The aim of the present work was to develop controlled release matrix tablets of Lornoxicam using polymers such as carbopol, Eudragit RS100 and ethyl cellulose as carriers in various concentrations. Matrix tablets were prepared by direct compression method. Prepared formulations were subjected to various evaluation parameters like hardness, friability, thickness, % drug content, weight variation etc. In-vitro dissolution studies were carried out for 12 hrs. The tablets were subjected to in-vitro drug release in 1.2 pH for first 2 hrs then followed by 6.8 pH phosphate buffer for next 10 hrs and the results showed that among the ten formulations F1 and F6 showed good dissolution profile to control the drug release respectively. Combination of polymers shows greater retarding of drug release. The compatibility of the drug and polymer were determined by UV- spectroscopy. Results showed that the drug was compatible with all polymers. The drug release follows mixed order kinetics and mechanism was found to be nonfickian diffusion. The stability studies were carried out which indicated the selected formulation (F1 & F6) was stable. In conclusion, the results suggest that the developed matrix tablets of Lornoxicam shows to improved efficacy and better patient compliance. Keywords: Lornoxicam, NSAID's, Controlled release, In-Vitro.