Effects of Antidepressant Drug on Sexual Behavior and Fitness Parameters of Drosophila ananassae

Drosophila is a suitable model organism in the field of toxicological science. The objective of this study was to explore the potential of Doxepin, an antidepressant drug, on sexual behavior and fitness of Drosophila ananassae. Sexual behavior such as mating latency and copulation duration was higher as concentration of antidepressant increases in both larval and adult feeding methods, decrease in the fecundity and fertility was also observed in adult feeding than larval feeding methods. According to the Chi-square, the percentage of the hatchability is decreased in treated compared with one control and significant difference in viability in adult feeding method. Our findings show the adult one which are exposed are more sensitive comparatively with larval stage. It was also noticed that antidepressant effects some behavioral aspects of Drosophila.