ENDOTHELIAL NITRIC OXIDE SYNTHASE GENE POLYMORPHISM. PART 2. POLYMORPHIC VARIANTS T786C, 4A/B

Background. The T786C polymorphism as well as polymorphism of the variable number of tandem repeats in the 4th intron (4a/b) of the endothelial nitric oxide synthase gene are important for the processes of NO formation in the organism. The aim. To analyze the literature and our own data on the distribution of allele frequencies and genotypes, as well as physiological and pathogenetic features of the T786C and 4a/b polymorphisms. Material and methods. To analyze the literature 41 scientific publications (2 native and 39 foreign ones) for the period from 2009 to 2016 have been selected. Results. The polymorphic variants T786C and 4a/b of the endothelial nitric oxide synthase gene are associated with the development of a number of pathologies and manifestation of physiological functions in the body. Conclusions. Certain distribution of allele frequencies and genotypes of the T786C and 4a/b polymorphisms accounts for a number of diseases. Studying the T786C and 4a/b polymorphisms is important for understanding the mechanisms of oxygen homeostasis in the body.