Study of liver dysfunction in type 2 diabetic patients in private hospital in Cuddalore district

Introduction: Diabetes is a syndrome characterized by disordered metabolism, hyperglycaemia, resulting from low levels of insulin production by beta cells of pancreas. The liver plays a major role in the regulation of carbohydrate metabolism, as it uses glucose as a fuel, it has the capability to store glucose as glycogen and also synthesize glucose from non-carbohydrate source. This key function of liver makes it vulnerable to diseases in subjects with metabolic disorders, particularly diabetes. Aim and objectives: The aim of this study was to find out the liver function test abnormalities in a group of diabetic patients and to determine the factors associated with these biochemical changes. Materials and methods: A total of 30 patients of both sexes suffering from T2DM and 30 age and sex matched normal individuals were selected for the study. The patients with fasting plasma glucose ≥126 mg/dl on 2 occasions were included in the study. Patients with any concomitant diseases which can alter liver function and patient with hepatitis, alcoholic were excluded from the study. Basic Liver Function Parameters Are Estimated Using Standard Methods. Results: The results of the present showed that the ALT, AST,PT and GGT levels in Type 2 Diabetic patients was increased significantly (p<0.01) as compared to normal controls. Conclusion: In conclusion, abnormal liver function results are more common among diabetes patients. Elevated liver enzyme markers are the markers for associated non-alcoholic fatty liver disease in diabetes patients. Testing for ALT and AST, should be carried out to screen underlying fatty liver, especially in male diabetes patients with high BMI.