THE ROLE OF SIGNALING MOLECULES IN THE DEVELOPMENT OF CHEILITIS CAUSED BY UV IRRADIATION AND SEBORRHEIC ECZEMA

The subject of the study is the establishment of the role of signaling molecules in the development of cheilitis in patients after sensitizing effects on the skin of the red border of the lips of various factors. For this purpose, blood levels of substance P, histamine, tumor necrosis factor-alpha (TNFα) in patients with actinic cheilitis and cheilitis developed against seborrheic eczema were studied. The reliability of the results of clinical and laboratory studies was established by methods of modern statistical processing. It was found that the development of clinical manifestations of lesions of the red border of the lips with sensitizing effects (UV rays and seborrheic process) is reliably associated with a synergistic increase in blood levels of signal molecules of different classes (not opioid neuropeptide, biogenic amine, pro-inflammatory cytokine). The obtained results substantiate new approaches to drawing up plans for examination, treatment and prevention of patients with development of cheilitis after sensitizing effects of UV rays and against seborrheic eczema. Key words: cheilitis (actinic and against the background of seborrheic eczema), signaling molecules (substance P, histamine, TNFα).