THE ROLE OF PROGESTERONE IN THE PROGNOSIS OF BREAST CANCER-A REVIEW

Introduction: According to published statistics by the World Health Organization in 2011, cancer is the second leading cause of death after cardiovascular diseases throughout the world. The American Cancer Society announced in its latest report that out of every eight women, one is diagnosed with breast cancer. The rate of cancer in developed countries is increasing from 1 to 0.2% and in developing countries about 0.5% annually. Methods: In this review article, the databases Medline, Cochrane, Science Direct, and Google Scholar were thoroughly searched to identify The Role of Progesterone in the Prognosis of Breast Cancer. In this review, the papers published until early January 2017 that were conducted to study The Role of Progesterone in the Prognosis of Breast Cancer were selected. Results:. Progesterone and its receptors connect to the nucleus of the cells of the target tissue to cause a series of changes in the expression of responding to the relevant hormone. The free hormone in the serum goes through the membrane without receiving help from any special protein to connect to its special receptors in the nucleus. Discussion and conclusion: Investigating these receptors are of more importance especially in patients with breast cancer who have developed the disease at ages prior to menopause and also in high risk groups, because knowing the status of these receptors in these groups of patients increases two to three times the chances of choosing hormone treatments in patients that have the highest level of responding to hormone manipulation. Key words: Progesterone, Prognosis, Breast Cancer