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Structure- Activity Relationship Sar Of Cyanoethylated Aromatic Amines

Journal: International Journal of Scientific & Technology Research (Vol.2, No. 11)

Publication Date:

Authors : ; ; ; ; ; ;

Page : 305-313

Keywords : Keywords Aromatic amines cyanoethylation; Azodin A and B exhaustion anti-bacterial structure-activity relationship.;

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Abstract Two types of aromatic amines were cyanoethylated. The cyano ethylated products were reacted with propylene oxide to give azocomponents N-acetyl - N - 26946 - hydroxyl propyl N- 26946-propylnitrile -1 3 - phenyl diamine and N- 26946 hydroxypropyl N- 26946- propyl nitrile aniline. These products are referred to as Azodin A and Azodin B respectively. When diazotized aromatic amines were coupled to Azodin B eight dyes were produced while Azodin A gave two dyes. Various elemental and spectroscopic methods were employed to elucidate the structure and properties of dyes. The UV-visible spectral data revealed that substitutions at the meta-position on the benzene rings of the azodyes favoured bathochromic shift more than those at ortho and para positions dyes 59 and10 vs. others.The dyes were used to colour polyester materials and the exhaustion properties were measured. The result revealed that the dyes have good exhaustion and leveling properties and that the cyano ethylated products have no NH2 group. Structure-activity relationship among the dyes were measured against some pathogens.The ability of these dyes to inhibit the growth of some micro organisms was correlated with anti-bacterial potential.

Last modified: 2014-03-17 17:42:18