An in-vitro study on the prevalence of antibiotic resistance by different aerobic bacteria isolated from various clinical samples

Introduction: The antimicrobial resistance by organisms to commonly used antibiotics is increasing day by day. This is a major challenge to clinicians for treating patients. The aim of the study was to find out the overall prevalence of drug resistant bacterial isolates among the clinical isolates and to identify the degree of resistance by each organisms. Materials and Method: The study was conducted in the department of Microbiology DM WIMS medical college for a period of 4 months starting from Jan-April 2017.The clinical samples were cultured and bacterial strains were identified. The antibiotic susceptibility profile of different bacterial isolates was studied. Results: A total of 3985 samples were processed. 372 samples were identified with 395 drug resistant bacterial isolates. Escherichia coli was the most common organism isolated and most of the isolates were ESBL producers. Among the Gram positive isolates, Vancomycin, linezolid and clindamycin were the most susceptible antibiotics whereas among the gram negative isolates the most susceptible drug were Piperacillin/tazobactem, Amikacin and imipenem. Conclusion: The present study reports suggests that antibiotic selection for empirical treatment should be based on drug sensitivity test results and it is evident that the drug resistance are more commonly seen in antibiotics and this has become a great challenge in treating pyogenic infections.