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Introduction: Diarrheal disease is a major cause of illness and death among infants and young children worldwide. Among the Escherichia coli (E. coli) causing intestinal diseases, there are six well-described categories Enteroaggregative E. coli (EAEC), Diffusely Adherent E. coli (DAEC), Enteroinvasive E. coli (EIEC), Enteropathogenic E. coli (EPEC), Enterohaemorrhagic E. coli (EHEC) and Enterotoxigenic E. coli (ETEC). Aim: To investigate contribution of different groups of Diarrheagenic E. coli (DEC) in pediatric patients with diarrhea. Materials and Method: This was Prospective laboratory based study approved by Institutional Ethical committee. A total of 100 stool samples were collected from patients admitted with acute diarrhea of 72 hours or less duration in 1- 60 months of age over a period of one year (Sep 2012 to Aug 2013). Escherichia coli were identified by standard Microbiological methods and identified E. coli were transported to National Institute of Salmonela and Escherichia coli center for further Serotyping. Results: The majority of children with diarrhea were in the age group of 7 to 12 months of age (46%). Watery diarrhea was present in 94% of children, followed by vomiting and fever (78%). The study showed that 48 100 children (48%) had diarrhea due to diarrheagenic E. coli. The most prevalent type was ETEC (20.8%) followed by EPEC (16.7%), EHEC (4.1%), and STEC (2.1%). The most prevalent serotypes of ETEC were O27, O23, O169. Among EPEC most prevalent serotypes were O90, O26. The most prevalent EHEC strain found in this study was O71. Conclusion: Study shows that diarrheagenic E. coli is a significant causal agent of diarrheal diseases in pediatric patients and it is a preventable by mere increase in hygiene, education, drinking safe water.