Study of serum adiponectin and lipid profile in newly diagnosed hyperthyroid patients

Introduction: Thyroid dysfunction is associated with metabolic changes that affect lipid and carbohydrate metabolism as well as adipocyte function. Adiponectin, an adipocyte derived hormone has been shown to decrease body weight by increasing thermogenesis and lipid oxidation. Changes in profile of lipid and adiponectin have been reported in patients with thyroid dysfunction. But the evidence is controversial. The present study aimed to explore the relationships between thyroid function and lipid profile and serum adiponectin levels in hyperthyroid patients. Materials and Method: A case control study was carried out on patients attending OPD, Department of Medicine RMRI, Bareilly. 100 cases of newly diagnosed hyperthyroid patients and 100 cases of age, sex matched apparently healthy controls were selected for analysis of biochemical parameters (plasma glucose, thyroid profile, adiponectin, lipid profile). Statistical analysis was performed using SPSS version 20.0. Results: We found that serum adiponectin level was significantly higher in hyperthyroid patients as compared to control (p<0.0001). Positive correlation was observed between thyroid hormones and serum adiponectin level. No significant differences was observed in lipid profile among hyperthyroid patients and control group. Conclusion: The present study demonstrated that hyperadiponectinemia is associated with hyperthyroidism. Regarding lipid profile no significant changes was observed in hyperthyroid patients as compared to control, though more extensive study with increased sample size may provide more insights.