Attenuation of depression by Bauhinia purpurea linn. leaves ethanolic extract in swiss albino mice

Introduction: Depression is a characterised by low mood and lack of activity that can implicit on person's thoughts, behaviour, feelings, and sense of well-being. Objectives: To evaluate antidepressant activity of Ethanolic extract of Bauhinia Purpurea in Swiss Albino mice. Materials and Method: Sixty Swiss Albino mice of either sex weighing 20-25gm were divided into five groups, Group I received vehicle (1% Gum acacia suspension - 3ml/kg P.O), Group II received standard drug Imipramine (10mg/kg orally 1 hour before the experiment). Group III, IV, V received the test drug in the dose of 100 mg/kg, 250mg/kg, and 500mg/kg respectively. Experiment was done by Forced swim test (FST) and Tail suspension test (TST) and duration of mobility and immobility were considered during the last 4 minutes in the 6 minutes test. Statistical analysis: Dunnett's test. P < 0.05 was considered as significant. Results: Administration of ethanolic extract of Bauhinia Purpurea at the dose of 500mg/kg produced significant decrease in immobility time in both the models with a P value of < 0.05. Conclusion: Administration of ethanolic extract of Bauhinia Purpurea at the dose of 500mg/kg has produced statistically significant decrease in immobility time in both the models.