Proteomics as an Indicator for the Research of Cell Apoptosisin Toxicology

Apoptosis is the major form of programmed cell death and is essential for tissue homeostasis in organisms. It not only plays important roles in cell development and immune system, but is also associated with several diseases. With the process of signal transduction, protein expression is an important indictor in apoptosis. To analysis the characteristic of biochemical events, proteomics--the simultaneous analysis and quantification of protein abundance widely used in cellular morphology and death, is applied. This review article highlights a series of new researches from the realm of proteomics crosses the field of toxicology to support that proteomics has been applied in verifying apoptosis pathway, exploiting diagnosis biomarker, evaluating drug therapeutic doses, biomarkers finding, and clinical disease management. As a holistic measure of cell apoptosis, proteomics will continue to make great strides as an indicator for the toxicology research. Proteomic technologies are still facing a number of challenges, such as removing impurities, acquiring low abundance proteins, discovering clinical and multi-omics technology, limit the popularization and application in toxicology. However, with innovation in technology, proteomic is still going to have a promising foreground.