Association of hyperuricemia and microalbuminuria in acute myocardial infarction in non-diabetic and non-hypertensive patients

Background: Hyperuricemia and micro albuminuria are known to occur independently in diabetes and hypertension. Of late the cardiovascular implication of Hyperuricemia and microalbuminuria in the non-diabetic, non-hypertensive patients has received focus. Hyperuricemia and microalbuminuria are independent risk indicators of ischemic heart disease, also indicates severity of the disease and has been considered as important prognostic indicator. Objectives: To measure and compare serum uric acid levels and microalbuminuria in either of patient and control groups and to identify the association of hyperuricemia and microalbuminuria in acute myocardial infarction in non-diabetic and non-hypertensive patients in a tertiary hospital. Materials and methods: A prospective study was conducted for a period of 8 months from February 2011-September 2011. We included 32 MI patients (diagnosed based on the clinical history and ECG changes) along with 32 age and sex matched healthy controls. A p-value of <0.05 was considered to be statistically significant. Serum uric acid and micro albuminuria were measured in these patients by colorimetric and immunoturbidimetric methods respectively. Results: The study group consisted of 50 patients, among them 32 participants were selected for our study. Our results showed significant change in serum uric acid levels and microalbuminuria when compared to healthy volunteers. In addition to that we observed positive association between serum uric acid and microalbuminuria; serum uric acid and body mass index in AMI patients. Combination of Killip class and serum uric acid level after acute myocardial infarction was a good predictor of mortality after AMI. Conclusion: These results indicate that assessment of these novel markers should be undertaken so that effective treatment and appropriate life-style changes can be implemented early to prevent morbidity and mortality.