FORMULATION AND INVITRO EVALUATION OF TOLTERIDONE TARTARATE SOLID DISPERSIONS USING DIFFERENT POLYMERS

The oral route of drug administration is the most common and preferred method of delivery due to convenience and ease of ingestion but it is problematic if the drug is poorly soluble or poor membrane penetrability. Although salt formation, solublization, particle size reduction have commonly used to increase dissolution rate and thereby oral absorption and bioavailability of low water soluble drugs there is practical limitation to these techniques. Among numerous ways of enhancing drug dissolution solid dispersion of drug in a water soluble polymer is one of the promising technique. Solid dispersion (SD) is defined as the dispersion of one or more active ingredients in inert carriers at solid state prepared by fusion, solvent or solvent fusion methods.The study was aimed to formulate solid dispersion tablet of Terbinafine Hydrochloride by using carriers polyethylene glycol 6000 (by melting method) and maltodextrin,urea in the drug carrier ratio of 1:1, 1:2 and 1:3. The prepared solid dispersions were characterized for their drug content, thermal studies, infrared spectral studies, aqueous solubility studiesand %yield.. From the results, it was clear that solid dispersion formulation showed improved dissolution rate compared to pure drug and physical mixture. Keywords: Soliddispersion,infrared studies,tolteridone tartarate,maltodextrin,urea,PEG6000