Profile Of Interleukins In Children With Hearing Sensory Deprivation

The paper investigated the interleukin profile of blood serum and saliva in younger schoolboys in the conditions of the auditory sensory deprivation. It examined 120 children aged 7-11 years. To achieve this goal formed two groups: basic - children with congenital bilateral sensorineural hearing loss grade 3-4 (60); Control - children with normal hearing (60). Assay of interleukin content in blood serum and saliva was carried out using solid phase ELISA method. After the study found differences in performance. After comparing score average level of IL-2 in serum in children found it a significant reduction in children with sensorineural hearing loss. Average performance IL-4, IL-5; IL-10 serum of children with hearing loss is significantly higher. Draws attention to the improvement of the level of IL-13 in serum of children with hearing loss. After comparison of interleukins in the blood of children 7 and 11 years with congenital sensorineural hearing loss found that children of eleven years of hearing loss is significant decrease in IL-2, IL-5 and increased IL-4, IL-10, IL-13. Since the main producers of anti-inflammatory interleukins are T-helper type II, then it is likely that this population of cells in children with hearing loss prevails. It is known that changes in the balance between T helper type first and second products are directly secretion of these cells. Comparative studies of interleukin saliva in children with impaired hearing revealed differences among children with normal hearing and children with hearing loss. The average level of proinflammatory IL-2 in children with sensorineural hearing loss was lower than children in the control group. The average level of anti-inflammatory IL-4, IL-5; IL-10; IL-13 in the study group was significantly higher compared to the control. It was found that with age in children with hearing loss on reaching eleven years is a significant increase in the level of IL-4 and IL-13. No significant changes in the level of IL-2, IL-5 and IL-10 in the saliva of children with hearing loss not installed.