The Influence of Alkilselenonaftiridin on Levels in Blood of Lipoproteins High, Low and Very Low Density on a Background of Experimental Diabetes

Correction of disturbances in lipid metabolism by diabetes remains a problem today. The aim of this work was to study the impact alkilselenonaftiridin (ASNR) on the dynamics of changes in the blood serum of levels lipoproteins of high (HDL), low (LDL) and very low (VLDL) density on the background of experimental streptozotocin-induced diabetes (DM). ASNR (180 mg / 100 g) were administered daily from the first day and 21ht day experiment in two different groups. It is shown that diabetes leads to changes in the lipid composition of blood - reducing the level of HDL and, conversely, increased LDL and VLDL levels. Introduction ASNR positively influenced the change of levels these of lipoproteins. Especially in the case when ASNR administered on the first day of the experiment. In particular, the introduction ASNR the first day of the experiment prevents significant reduction of HDL levels, such as 8.3 and 9.9% on the 20th and 40th day of the experiment, respectively. ASNR prevents increasing of LDL levels on 13.3 and 10.4% on the 20th and 40th days experiment, respectively. Simultaneously, ASNR reduces the negative impact of DM on VLDL levels on 7.4, 11.1 and 21.4 % on the 20th, 40th and 60th day experiment in accordance. However, the introduction of ASNR with 21st day of the experiment has little effect on changes of levels lipoproteins, caused by the development of DM. Except reduction on 13.3 % the negative impact of diabetes on levels of VLDL on the 60th day of the experiment. Thus, the introduction of ASNR positively influenced the change of levels lipoproteins of high, low and very low density on the background of experimental streptozotocin-induced diabetes.