Association of CYP11b2 Gene Polymorphism of Aldosteron-Synthase with the Risk of Myocardial Infarction with ST-Segment Elevation

The purpose of the study is to determine the link between CYP11B2 -344ТС gene polymorphism and risk factors, course of myocardial infarction with ST-segment elevation (STEMI) with considering of genetic inheritance models. Materials and methods. 85 patients with STEMI were examined, 68 (80%) men and 17 (20%) women, at the average age (58,94±10,16) years old. Allele polymorphism -Т344С of CYP11B2 gene was determined by polymerase chain reaction in real time. Statistics was obtained thanks to software package Statistica 8.0 (Stat SoftInc, USA), Microsoft Office Exсel 2003. For a deeper understanding of association of CYP11B2-gene polymorphism, codominant, dominant and recessive models of inheritance were used. Results and discussion. Due to odds ratio the relative risk of occurrence of STEMI in researched patients with TT-genotype rises with the presence of arterial hypertension (AH) OR=8,89; 95% CI [1,41-36,57], Р1-3=0,02 (codominant model of inheritance). In the group of patients with TT-genotype compared with ТС+СС anxiety-depressive conditions met more often (Р=0,02), tendency to more often AH was too (Р=0,06) (dominant inheritance model). Due to odds ratio, probability of occurrence of STEMI in researched patients with ТС+ТТ-genotype becomes higher in the presence of AH, OR=3,27; 95% CI [1,05-9,86], Р=0,037 (recessive inheritance model). Conclusions. ТС+ТТ-genotype compared with СС represents 3,27-fold higher relative risk of occurrence of STEMI in the presence of AH (Р=0,037). Arterial hypertension leads to 8,89-fold more often relative risk of STEMI in patients with ТТ-genotype compared with СС (Р=0,02). Anxiety-depressive conditions in patients with STEMI occur more often in ТТ-genotype compared with СС, ТС+СС polymorphism, ТС+ТТ compared -344СС.