The Reamberin’s Usage Effectiveness with the Purpose of Cognitive Functions’ Correction in the Acute Period of Polytrauma

Injury is one of the causes of critical states and cognitive impairments development as well as their consequences. Cognitive impairments that occur in critical patients can not only significantly slow down the recovery process and worsen the quality of life after hospital, but also directly related to higher lethality. One of the important factors that oppress cognitive functions in traumatized patients may be posttraumatic stress disorder. Objective. The purpose of the article is to examine the reamberin's effect on the cognitive functions' state in the acute period in patients with polytrauma, not burdened by intracranial lesion. Materials and Methods: 49 patients were examined (26 in the control group and 23 in the main group). The level of cognitive functions before trauma was assessed by the CFQ questionnaire for 2-3 days after injury and in telephone mode 3 months after discharge; the MMSE scale was applied on the 2nd day in the intensive care unit, when transferring from the department and before discharge. The severity of the injury was assessed by the ISS scale. The severity of the response to traumatic stress was assessed by the IES-R scale. The data were processed using parametric and nonparametric statistics. Results. In both groups the baseline level of cognitive function was within the age range. Groups were comparable by age and severity of injury. In the early post-traumatic period, there was a significant decrease in cognitive functions in both groups according to baseline level. During treatment the inhibition of cognitive functions decreased. Cognitive function in the group receiving reamberin was slightly higher especially at the stage of transfer from the ICU, where this difference was statistically significant (p = 0.03). After 3 months the cognitive function in both groups decreased slightly relative to the level that was observed during discharge from the hospital. The psychological response to trauma and stress at the time of being in the intensive care unit was low in both groups. After 3 months the response to stress in both groups increased, with the initial difference with greater severity in the main group being replaced by an excess in the control group (the total in the main group increased by 15.8%, while in the control group it increased by 25.2%).