Effect of Therapy on Clinical State and Endothelial Function in Patients with Coronary Heart Disease

The article examines the influence of different therapeutic options on the clinical status, quality of life and endothelial function in patients with coronary heart disease. The purpose of the study was to assess the effect of therapy on the clinical status and endothelial function of patients with coronary heart disease and additional possibilities for correction of endothelial dysfunction with a fixed combination of meltedonium and gamma-butyrobetaine. We supervised 112 patients with coronary heart disease: 76 of them were with stable coronary heart disease of II-III functional classes and 36 patients were hospitalized with an acute coronary syndrome. We evaluated the effectiveness of additional inclusion to the treatment of patients with coronary heart disease combination of meldonium and gamma-butyrobetaine ("Capicor®"). It is shown that the "Capicor" addition in the complex treatment of patients with coronary heart disease contributes to more pronounced improvement in quality of life according to the Seattle Angina Questionnaire, namely: a significant reduction of angina frequency scale, increased of treatment satisfaction, and improved of disease perception scale. At the same time, the "Capicor" addition to the treatment leads to a more significant positive dynamics of the endothelial functional state compared with patients receiving traditional therapy. The obtained data give grounds to consider that "Capicor" inclusion in the management scheme of patients with stable and unstable course of coronary heart disease is expedient.