Using of some novel derivatives of thiourea for Synthesis of pharmaceutical compounds of 5-Arylidine-2-imino-4-thiazolidinones and their medicinal properties study as anti-inflammatory agents

Thiazolidinone belongs to important groups of heterocyclic compounds. Recently this compounds displays activities such as antioxidants, anti-inflammatory, anti-virus and tuberculostatic. In this project we reported an effective reaction to synthesis of novel thiazolidinone-4-one in the presence of deep Eutectic Solvent as catalyst by Aldol condensation, derivatives of thiourea asymmetric and aldehydes.The primary deivatives phenyl thiourea were obtained by the reaction of derivatives Aniline with Ammonium thiocyanate and HCl in refluxing free solvent and Next reaction between deivatives phenyl thiourea and chloro acetyl chloride in refluxing ethanol. Subsequent synthesis of 5-Arylidene-2-imino-4-thiazolidinones was performed by condensation of amino thiazolidinone with aldehydes in the presence of catalysts Deep Eutectic Solvent. This method have several advantage such as synthesis free solvent, short duration of action, the use of catalysts deep eutectic solvent, being environmentally friendly and simple procedure.The structure of synthesized compounds (3f-h) characterized by infra-red spectroscopy (FTIR), 1H Nuclear magnetic resonances, and 13C Nuclear magnetic resonances.