DYNAMICS OF CHANGES IN FREE AMINO ACIDS CONCENTRATIONS IN THE MICROBIAL-TISSUE COMPLEX AFTER ADMINISTRATION OF INFESOL40 TO ANIMALS

Infezol is a balanced meeting modern standards amino acid solution with low osmolarity, which makes it possible to use it for stimulating protein synthesis in complex treatment of a wide range of patients. The aim of the study was to analyze the dynamics of changes in the spectrum of amino acids in the microbial-tissue complex (MTC) of rat small intestine after intragastric administration of Infesol40. Material and methods. The experiment was carried out on 30 rats weighing 120-140 g, which were administered intragastrically Infezol40 at a dose of 20 ml/kg body weight. Decapitation was performed over 10, 20, 30 or 45 min,respectively. Determination of free amino acids in the microbial-tissue complex of the small intestine was performed by the reversed-phase HPLC method. Results. Intragastric administration of Infezol40 lead to an increase in the total amount of proteinogenic amino acids in the MTC of the small intestine, which persisted for 45 minutes. Conclusions. The introduction of the amino acid mixture modulates absorption processes from the intestinal lumen, resulting in a disproportionate increase in the concentration of phenylalanine, which in turn may stimulate biosynthetic processes in the small intestine MTC, as evidenced by an increase in the level of tyrosine which is not included in the composition of Infezol40.