IMMUNOHISTOCHEMICAL DIAGNOSTICS OF HORMONE-RECEPTOR STATUS OF BREAST CANCER PATIENTS OF THE GRODNO REGION IN 2008-2014

Background. It is known, that three-negative breast cancer (TNBC), which cannot be cured by targeted therapy by Herceptin and hormonal treatment, and requires aggressive chemotherapy. Aim. Identification and clinical and morphological analysis of immunohistochemical diagnostic receptors ER, PR and Her2/neu triple negative cancer in Grodno Regional Pathoanatomical Bureau data in 2008-2014 years. Material and methods. Database materials of immunohistochemical (IHC) study of hormone-receptor status (ER,PR, and Her2 / neu) in breast cancer, which was carried out in Grodno Regional Pathoanatomical Bureau in 2008- 2014, with the partial revision of the micro slides. Results. The level of coverage by IHC study of estrogen receptor, progesterone and Her2/neu in breast cancer (BC) in the Grodno region over the study averaged 86.2% and 88.5%, respectively, and the results of determination – overexpression Ner2/neu( Score 3) amounted to – 28.2%. Conclusion.The obtained results suggest a methodically correct performance of studies, as they correspond the data of world literature.