Recent Progress in Chemistry and Biology of Indazole and its Derivatives: A Brief Review

The biological and medicinal properties of indazoles have prompted enormous research aimed at developing synthetic routes to these heterocyles. This review focuses on the biological properties associated with this system, chemical reactions, functionalizations, and medicinal application of indazole nucleus. Moreover many useful drugs have emerged from the successful investigation carried out in this branch. Indazole ring system is not a common feature in nature but a large number of synthetically prepared compounds have shown desirable pharmacological properties, so efforts have been made in the last few decades to synthesize a different new and novel heterocyclic indazole compounds & its derivatives which were evaluated for various activity. Study of biological activity of substituted heterocyclic compounds represents a core area in the field of drug development and discovery. This overview summarizes structures of pharmacologically interesting indazoles published during the last decade, as well as syntheses, reactions, and functionalizations.