Histological and Immunohistochemical Studies on the Cornea and Retina of Sofosbuvir Treated Rats

Sofosbuvir (Sovaldi) is used in treatment of hepatitis C infection. The aim of this study is to demonstrate the effect of Sofosbuvir on the cornea and retina of adult male albino rat. Twenty adult male albino rats were used in this experiment. Animals were divided in two groups: Group I (Control) included ten rats were kept without any treatment throughout the experimental period and Group II (Sovaldi treated) included ten rats that received Sofosbuvir in the form of tablets with the trade name ‘Gratisovir'. Each tablet contained 400 mg of Sofosbuvir; these tablets were dissolved in distilled water and given for rats orally by gastric tube in a dose of 4mg/kg per day for 5 weeks. Sofosbuvir results in histological and immunohistochemical changes in cornea and retina of Sovaldi treated rats.