The Relative Fewness of Renal Metastases in Lung Cancer is Probably Explicable with the “Erythrocyte Associated Necrosis Factor” which may be an Oncobiomarker

There is profundity of lung cancer cells thrown into the circulation with each heart beat and the quantity of the quarter of the cardiac stroke volume being delivered to the kidneys. Despite both of these attractive attributes, renal deposits are so few as to constitute an anomaly asking for solution through recondite research. Such a situation was clearly pointed out in his 1955 Harveian Oration by Melville Arnott who mentored the profession by promoting the theory that an anomaly is actually Nature's own way of pointing to the researchable phenomenon of lung cancer spreading preferentially to the ipsilateral adrenal gland. This was acknowledged in Professor Cappell's 1958 Edition of Muir's Text-Book of Pathology. Thereafter, during fully fledged training at his Department, the author realized that a Mono-Block Formalin-Fixation Method was ideal for lung cancer investigation. As serendipity would have it, the 45 cm long thoracic duct was coiled up in Swiss-roll fashion and therefore became processable on a single microscopic slide. This opened up a panorama, namely, that lung cancer cells were being carried more or less leisurely through this curious conduit at the moment of death. In particular, there was cogent conclusion that “Necrosis of the cancer cells was apparent in 3 cases, but it was clear that this had occurred in association with large aggregates of the malignantcells and that among such aggregated cells red blood corpuscles abounded”. This 1967 conclusion awaited the revolutionary development of the intravital videomicroscope in the realm of human research. Thus, on obtaining consent from lung cancer patients, cannulating them would ensure the retrieval of the above necrosis-associated pabulum. Thereafter, the performance of translational research would follow, especially as funding has reportedly been generous. In other words, Nature has offered opportunity to obtain materials for that target therapy which could be geared towards cancer cure. To this end, it has been hypothesized that there is an underlying “Erythrocyte Associated Necrotic Factor” (EANF). Moreover, to counter the usual problem of doubt, such a hypothesis needed to have supporting data with an explanatory power. Such data were, therefore, provided at some length. Here, the hypothesis is grounded on the unique position of the glomerulus. In addition, there is the closing emphasis on pursing whether EANF is an oncobiomarker whose usage can be expedited with the help of consenting patients from whom the vital pabulum would be retrieved and its intrinsic nature identified and utilized.