ANTIDEPRESSANT EFFECT OF ZIZIPHUS MAURITANIA AGAINST FORCED SWIM TEST INDUCED DEPRESSION IN WISTAR RATS

The aim of the present study was to develop an sustained release formulation of Hydrocodone to maintain constant therapeutic levels of the drug for over 8 hrs. Various grades of eudragit and HPMC were employed as polymers. Hydrocodone dose was fixed as 4 mg. Total weight of the tablet was considered as 100 mg. Polymers were used in the concentration of 10mg and 20mg concentration. All the formulations were passed various physicochemical evaluation parameters and they were found to be within limits. Whereas from the dissolution studies it was evident that the formulation (F3) showed better and desired drug release pattern i.e.,98.43 % in 12 hours. It followed zero order release kinetics mechanism. Keywords: Hydocodone, Eudragit, HPMC, Sustained release tablets