MicroRNA: New Era for Therapeutic Strategy in Ischaemic Heart Disease
Journal: Journal of Hypertension and Cardiology (Vol.2, No. 3)Publication Date: 2017-02-09
Authors : Sarmistha Mitra; Md Kamrul Hossain;
Page : 20-31
Keywords : miRNA; Ischaemic Heart Disease; Therapeutics;
Abstract
Abstract Over the last few decades, many research works highlighted the role of miRNAs on cardiac diseases. Ischaemic heart disease (IHD) or coronary heart disease is a condition that is mainly caused by atherosclerosis. It has been established that microribonucleic acids regulate many factors that are involved in the development and pathophysiology of IHD. As a result, there are great potential opportunities for miRNAs to be used as a biomarker for disease differentiation, as well as novel drug targets or therapeutics for the treatment and also as a diagnostic approach. As it is now evident that miRNAs play critical roles in the disease mechanisms, this review article tried to focus on the pathway, in which; the miRNAs stimulate the IHD to develop. By understanding the mechanisms, it will be possible to present a complete strategy of IHD treatment and also solving all the impediments that are highlighted in this article. Still, there are a number of limitations and obstacles on the way of developing a proper therapeutic approach that can be approved and well accepted. This review is mainly dependent on the potential of miRNAs as a promising arena on the field of cardiac treatment and the possible obstacles that are needed to be explored and overcome
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Last modified: 2017-12-08 15:37:35