Clinical Cases of Crohn‘s Disease in Pediatric Hirschprung‘s Patients

Crohn's and Hirschsprung's diseases are two different conditions of intestinal tract though both of them are genetically predisposed. Each disease have genetic mutations in some genes, however there are no evidence that there are mutations common to both conditions. We present 3 clinical cases of patients who underwent surgery in infancy for Hirschsprung's disease. Later in early childhood all the patients developed clinical symptoms of inflammatory bowel disease and Crohn's disease was diagnosed. Both conditions were confirmed histologically. After introducing the treatment for Crohn's disease positive effect was shown. These cases raise the hypothesis that the two conditions may have similarities in etiology and pathogenesis and may represent a spectrum of intestinal inflammatory diseases in children.