Risk Factors of Reсurrent Cardiovascular Events in Patients during Half-year after Acute Myocardial Infarction in the Presence of Obesity

To date, the search for new markers and risk factors for recurrent cardiovascular events in patients with metabolic disorders, namely obesity, is a key challenge of modern cardiology. The aim of the study was to investigate the association of galectin-3 and creatinine levels, body mass index, waist volume with recurrence of cardiovascular events during 6 months of observation of patients with Q-positive acute myocardial infarction (AMI), depending on the presence or absence of concomitant obesity. The object and methods of research. During the study, 105 patients with AMI aged 64.22 ± 1.42 years were examined. The first group consisted of 75 patients with concomitant obesity, the second – of 30 patients with normal body weight. Obesity of the 1st level was detected in 39 people, 31 persons had obesity of the 2nd level, and obesity of the 3rd level was in 5 people. The level of creatinine was determined by the biochemical method. The level of galectin-3 was determined by method of immunoassay analysis. The calculations of the mortality risk and the occurrence of a repeated myocardial infarction were also performed on the GRACE scale. Results. Our study lasted 6-months. During this period we viewed the patients after AMI with concomitant obesity, 37.56% of patients had recurrent events in the form of unstable angina and / or recurrent AMI. In this sample, unstable angina was fixed in 43.18% cases, and a second-time AMI – in 56.82% of patients. In addition, the body mass index level exceeded 30 kg / m2 in all patients, serum creatinine ranged from 57 μmol/l to 276 μmol/l, the GRACE score was higher than 127 points and averaged 136.7 ± 4.94 points, while galectin-3 ranged from 18.56 ng / ml to 33.74 ng / ml and averaged 23.83 ± 5.27 ng/ml. Using ROC analysis, it was found out that at serum creatinine levels > 85 μmol/L, galectin > 12.83 ng/ml, body mass index> 34.13 kg/m2 and waist volume> 130 cm, it is possible to predict cardiovascular events within six months after acute myocardial infarction in patients with concomitant obesity. Conclusions. We established a stable relationship between the anthropometric indicators, namely the body mass index and waist volume, and the serum levels of creatinine and galectin-3 with the occurrence of repeated recurrent cardiovascular events during the 6-month follow-up period for patients with Q-positive myocardial infarction on the background of obesity.